Stem Cell Therapy

Stem Cell Therapy has also been called cellular medicine and Regenerative Medicine and it is a FACT that every moment of the day and night stem cells are working in your body to repair and regenerate organs, tissues, bones, cartilage, tendons, muscles, nearly every cell in your body. Approximately every two years your entire body has been turned over with new cells and stem cells are at the beginning of that natural process.
We recently have the science to be able to safely access these stem cells, concentrate them and culture expand them and put them back into our bodies to repair and regenerate our old and damaged body parts.

NOT NEW … In 1868 Theodor Boveri and Valentin Häcker used the term Stem Cell to describe cells committed to give rise to a germ line. In 1997, Morrison while studying the regulation of embryonic development, defined Stem cells as having the capacity to both self-renew and give rise to differentiated cells.

For 20 years hospitals and experimental labs have been using stem cell therapy for skin replacement in burn victims, heart muscle repair in specific types of cardiac victims, lung tissue repair for those suffering with chronic issues such as COPD and many other. Professional sports teams have had access for their athletes due to the incredible expense of this break through science.

What IS NEW is that we now have access outside the experimental laboratory settings to be able to easily mechanically and enzymatically isolate stem cells, culture expand them to 100’s of millions and then re-inject them back into the damaged or degenerated tissue.

Bellevue Pain Institute focuses on combining the proper diagnosis, prognosis and care plan by considering all the unique factors those individual patients present us with.

This would include such things as age, past and current lifestyle choices, area(s) of complaint, the extent and nature of the problem, overall health factors such as diet and exercise and the underlying cause of the problem to determine individual patient’s candidacy for care and then the creation of a comprehensive and well prepared treatment plan.

For example, a 75-year-old female patient with extensive degenerative arthritis in the knee(s), overweight by 40 pounds and a past history of extensive cigarette usage would have a much different care plan than a 65-year-old female patient that has spent her life with proper nutrition and exercise.

In addition to specific orthopedic joint injection of the stem cells, Bellevue Pain Institute additionally systemically deploy live stem cells into the free circulation which have been shown to be attracted to areas of body inflammation and have the ability to cross the blood brain barrier.

Bellevue Pain Institute uses autologous (cells extracted from a person and deployed back into that same person) adipose derived mesenchymal (adult) stem cells as our foundational stem cell acquisition procedure however not all patients have adequate quality or quantity of stem cells available in their adipose tissue.
Bellevue Pain Institute use on-site hemocytometer cell counters to make this determination for each of their patients.

Additional treatment options within Bellevue Pain Institute include:
1. Live cell umbilical cord derived stem cells homologous (AKA allogenic-cells derived from another human) properly processed from the American Tissue Bank under stringent FDA protocols.
2. Cryogenic storage also known as cell banking and culture expanding of the most robust cells in the sample, inclusive of cryogenic storage for future usage for repeat dosing or new traumas.
3. Biomechanical evaluation and treatment protocols to assess for instabilities of ligaments, compression syndromes of the spine or large joints, chronic inflammatory processes derived from poor nutrition or autoimmune disorders.

Bellevue Pain Institute understands that stem cells can be derived from a variety of procedures.

Stem Cell Therapy Education 101:

1. Adipose derived stem cells-in the well vascularized fatty tissue just below the surface of the skin along the side low back or abdominal areas is a plethoric source of adult stem cells. A minimally traumatic, manual mini-lipo-suction procedure is used to extract 4-8 ounces of adipose tissue. A proprietary processing procedure is utilized to both mechanically and enzymatically separate out the stromal vascular fraction (SVF). This is a fluid that now contains 5-50,000,000 adult stem cells, growth factors, electrolytes, carbohydrates, proteins, endothelial cells, and cytokines. This is arguably the richest source of stem cells that can be extracted with the minimal amount of trauma to attain the cells. The minimal invasiveness of this procedure is paramount as stem cells, by their very nature, are attracted to trauma and inflammation; therefore the minimal use of all anesthesia maximizes the quality and quantity of the extracted stem cells.

Adipose tissue, by its very nature, is metabolically slow and therefore there are scientists that suggest that stem cells derived from adipose tissue will be biologically younger than the host that they are extracted from which adds to their effectiveness in reversing the aging processes within the human body. Bellevue Pain Institute does use these cells.

2. Umbilical cord stem cells-these are stem cells derived and collected from the donated umbilical cord tissue and blood of live healthy birthed babies both C-section and vaginal. This human tissue is delivered to the American Tissue Bank, processed under the most stringent regulations as controlled by the FDA, and then purchased by Bellevue Pain Institute in aliquots of 30+ million cells. The cells are stored at -86°C, reconstituted in room temperature and then deployed into the recipient in less than 20 minutes of thawing out. These are live active stem cells, which begin their anti-inflammatory functions, cellular division into more stem cells, cellular division into the damaged tissues (blood vessels, cartilage, bone, meniscus, synovial fluid, tendons, ligaments, etc.) immediately upon deployment into the recipient. In cases where the quantity or quality of the recipient stem cells is of concern, Bellevue Pain Institute will consider the supplemental use or the exclusive use of live umbilical cord stem cells when the degenerative processes or the inflammatory processes are extensive and the autologous adipose derived stem cells are in question. Bellevue Pain Institute does use these cells.

3. Bone marrow derived stem cells-deep within the central skeleton, such as the pelvis, sternum, cranium, ribs, vertebrae and scapulae, red bone marrow is rich with stem cells specifically hemopoietic (blood making) cells. Bone marrow derived stem cells are essential in the treatment of blood diseases and have been used throughout the United States for many years. Any invasive procedure especially when massive amounts of local anesthesia or worse general anesthesia is required, will sacrifice quality and quantity of the stem cells. By the very nature of the bone marrow stem cells physical location, trauma cannot be avoided in the process their extraction therefore full and complete recovery of the extraction site should be obtained prior to any autologous (same person) deployment otherwise there is great risk of losing many millions of the cells to healing the extraction site. Bellevue Pain Institute feels that bone marrow derived stem cells are best utilized for homologous use. Bellevue Pain Institute does not use bone marrow cells in their treatment protocols.

4. Platelet enriched plasma (PRP)-a simple blood draw is taken and individual parts of the blood (Plasma is the liquid component of blood, in which the red blood cells, white blood cells, and platelets are suspended. It constitutes more than half of the blood’s volume and consists mostly of water that contains dissolved salts (electrolytes) and proteins. The major protein in plasma is albumin) are mechanically separated. There are few to no stem cells in the PRP fluid however platelet enriched plasma has been used for many years throughout the United States in the treatment of inflammatory pain. The true mechanism of PRP pain relief is not completely known however excitatory cytokines in the local area of the injection will cause the attraction of some stem cells to the area. The scientific literature around PRP has proven to be about 50% effective and should be considered a temporary management but not a cure/not regenerative. Bellevue Pain Institute does use PRP procedures in some isolated cases.

5. Amniotic stem cells-the amniotic fluid that a child is surrounded by in the mother stomach and is collected upon natural birth either C-section or vaginal. This fluid has no living cells, can be stored at room temperature and contains high quantities of human growth factor therefore has been found to bring relief in arthritic/orthopedic inflammatory conditions, although temporary. Bellevue Pain Institute does not use these fluids in their treatment protocols.

6. Embryonic stem cells-these are stem cells derived from aborted fetuses/unborn human children. These types of stem cells are illegal in all 50 states with the exception of some laboratory settings. Bellevue Pain Institute does not use these fluids in their treatment protocols.

Stem cells are attracted to inflammation and activated by trauma. The main reason to use adipose derived stem cells is because the attainment process is so non-traumatic that the cells are then more available to go to the site of pain and degeneration like the knees, hips, shoulders spine or else where rather than the traumatized attainment site such as in Bone Marrow derived.

An additional IV injection procedure of the stem cell harvest is the second line of reinforcements! We will first inject the stem cells into the target area such as the knees, hips, shoulders, ankles or spine, then the other 1/2 of the attained cells will be injected into the patients system using IV (intravenous) methods. This will send millions of these intelligent stem cells into the patients body being attracted to all areas of systemic inflammation throughout the body. A large majority of the stem cells will spend time sequestered in the lungs and then will be released like a second wave of reinforcements into the body being attracted to inflammation like a painful and degenerated knee.

ANNOUNCEMENT …Bellevue Pain Institute is very proud to announce its acceptance into the Cell Surgical Network and the IRB [Institutional Review Board] an administrative body established to protect the rights and welfare of human research subjects recruited to participate in research activities conducted under the auspices of the institution with which it is affiliated.

Within the Cell Surgical Network over the last 7 years we have performed well over 7000 recorded and tracked adipose derived stem cell procedures and have recently published our safety study showing 100% free of significant side effects.

Although everyones response to the therapy will differ we are able to statistically state what generally attained results are for each studied condition. We do know that the younger patients respond better than older because the number and quality of the stem cells decrease as we get older.

Stem cell banking and culture expanding is only legally possible though the Cell Surgical IRB as it requires human cell transfer storage and growth so that we can return to you no matter how old you are, tens or hundreds of millions of stem cells when we cryogenically store and then culture expand the volume of the cells and then put them back into you.

Stem Cell Therapy is not a magic bullet, it takes time for the body to fully take advantage of the therapy and the science is very complicated. Most patients feel the most benefit within 4 months post procedure but we have tracked continued improved range of motion, diminishment of pain and improvement in muscle strength and density as long as 2 years after a single procedure.

To see all the areas of study that are within the Institutional Review Board [IRB] see:

www.StemCellRevolution.com/currently-studying/

IN THE NEWS

https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm585345.htm

https://futurism.com/scientists-discover-way-prevent-stem-cell-loss-improve-tissue-regeneration/

https://www.usnews.com/news/healthcare-of-tomorrow/articles/2017-10-04/stem-cells-may-hold-the-fix

https://futurism.com/a-new-stem-cell-treatment-had-striking-anti-aging-results/

http://www.startribune.com/mayo-u-develop-robocop-stem-cells-to-fight-cancer/441090583/

http://www.cnn.com/2017/11/10/health/skin-replacement-transplant-success/index.html